Job Description

Start date: January 2026. Appointment term: 1-2 years

The Greicius Lab at Stanford University seeks a motivated postdoctoral fellow to join its multidisciplinary team studying the genomics of neurodegenerative diseases, with a special focus on Alzheimer’s Disease (AD). Current research focuses on using novel methods to detect genetic associations with disease, including AI-powered tools and new statistical techniques that leverage large datasets, heavy computational capabilities, and/or a robust understanding of biological systems to provide unique disease insights.

The lab has state-of-the-art computing capabilities with an in-house cluster serving 80 CPU cores and 1.5TB of RAM, as well as a newly acquired NVIDIA DGX box with eight H100 GPUs and 224 CPU cores. We analyze large public datasets, such as the Alzheimer’s Disease Sequencing Project and UK Biobank, and serve as the Biomarker Core for the Stanford Alzheimer’s Disease Research Center, curating and analyzing a deeply-phenotyped dementia and healthy older control dataset. We have generated over 1200 long-read sequencing (LRS) genomes of diverse phenotypes and have additional multiomic data spanning proteomics, transcriptomics, and fluid biomarkers.

A major focus of the lab addresses the impacts and mechanisms of APOE. We leverage extreme phenotypes, i.e. healthy 75+ year-old APOE ε4 carriers and early-onset cases without a known genetic cause. We are also interested in genetic interactions (epistasis), tandem repeats, machine learning, and other areas of AD research that have not yet been explored extensively. You will be part of a medium-sized team (typically 7-10 members) that meets regularly and works closely with each other and with the PI. The position includes opportunities for travel to conferences, interactions with clinicians, and close collaboration with partner research groups in protein chemistry, molecular biology, and bioinformatics.

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